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Using medical records from more than 70 health care organizations, researchers looked at the frequency of serious bleeding among stroke survivors over a 20-year period beginning in 2003  Among 666,150 stroke survivors, 35,631 took SSRI or SNRI antidepressants, including sertraline, fluoxetine, citalopram and venlafaxine --- ncbi nlm nih gov pmc articles PMC6953348Feb 3, 2022 ·     Multiple studies have reported that the use of  selective serotonin reuptake inhibitors (SSRIs)  is associated with an increased risk of ischemic  stroke ; however, this finding may be the result of a confounding by indication  We examined the association using different approaches to minimize such potential bias   --- ahajournals org doi full 10 1161 strokeaha 112 674242pubmed ncbi nlm nih gov 34675868We hypothesized that sertraline, which is characterized by less severe adverse effects and more stable pharmacokinetics than classic SSRI, is associated with improved functional recovery in acute ischemic stroke patients with motor deficits  Methods: Prospective observational study of consecutive acute ischemic stroke patients who received    The relationship between the use of selective serotonin reuptake inhibitors (SSRIs), the most widely prescribed antidepressants, and ischemic stroke has been a matter of controversy for the last 2 decades, with many studies suggesting an increased risk, 1–5 while a few showing a decreased risk 6,7 or a neutral effect  8 These findings seem to be a pharmacological paradox as SSRIs have a    --- ahajournals org doi full 10 1161 strokeaha 112 673947We also wanted to find out whether SSRIs had other benefits, for example improving the severity of any arm or leg weakness, mood, anxiety, cognition, quality of life, and whether SSRIs were associated with side effects such as bleeding or seizures  Study characteristics  In total we found 76 studies recruiting 13,029 stroke survivors within one    --- ahajournals org doi 10 1161 STROKEAHA 121 036661--- heart org     common-antidepressants-appear-safe-for-most-stroke-survivorsDoes sertraline improve functional recovery in acute ischemic stroke patients?  Feb 1, 2024 ·     By American Heart Association News  (seb_ra iStock via Getty Images) Most  stroke  survivors may be able to safely take commonly prescribed  antidepressants  to aid in their recovery, according to new research that could allay concerns over  abnormal bleeding  risks associated with these drugs   bmcneurol biomedcentral com articles 10 1186 s12883-015-0345-xPeople also askBackground Evidence about the association between antidepressants and the risk of stroke recurrence was scanty  This study evaluated the risk of stroke recurrence according to using antidepressants in patients with stroke from a national representative cohort  Methods This cohort study followed 16770 patients aged > =20 years who had an incident stroke from 2000 to 2009 from the National    Jan 10, 2013 ·     Our findings among ischemic  stroke  patients are in line with a former study among MI patients, showing a significant lower risk of new MI among users of SSRIs  12 However,  stroke  pathophysiology may differ from the pathophysiology of ischemic heart disease, and cerebral vasospasms caused by SSRI treatment could, at least in theory, counteract a      Can SSRIs cause a clot-caused stroke?  --- ncbi nlm nih gov pmc articles PMC6310584Why was sertraline not prescribed in a stroke neurologist?  1  Introduction  The incidence of poststroke depression (PSD) is very high around the world  [1–3] A meta-analysis of epidemiology revealed 31% of patients had depression during 5 years following the stroke, in which 61 cohort studies and 25,488 patients were enrolled  []Do selective serotonin reuptake inhibitors increase ischemic stroke risk?  Jan 29, 2013 ·     The influence of post- stroke  prophylactic anti-depression treatment on nerve functional rehabilitation  Acta Academiae Medicinae Qingdao Universitatis  2006; 42:253–254  Google Scholar; 28  Wiart L, Petit H, Joseph PA, Mazaux JM, Barat M  Fluoxetine in early poststroke depression: a double-blind placebo-controlled study   Stroke   2000; 31:1829      Oct 5, 2021 ·     We hypothesized that  sertraline,  which is characterized by  less severe adverse effects  and more  stable  pharmacokinetics than classic SSRI, is associated with  improved functional recovery  in acute ischemic  stroke  patients with motor deficits   Our findings among ischemic stroke patients are in line with a former study among MI patients, showing a significant lower risk of new MI among users of SSRIs  12 However, stroke pathophysiology may differ from the pathophysiology of ischemic heart disease, and cerebral vasospasms caused by SSRI treatment could, at least in theory, counteract a potential antithrombotic effect in stroke    Methods: Prospective observational study of consecutive acute ischemic stroke patients who received sertraline for clinically suspected post-stroke depression (PSD) or at high risk for PSD  Eligibility comprised acute motor deficit caused by ischemic stroke (≥2 points on NIHSS motor items) and functional independence pre-stroke (mRS ≤1) --- cochrane org     STROKE_selective-serotonin-reuptake-inhibitors-stroke-re   Oct 5, 2021 ·     The necessity of a fasting phase in acutely treated  stroke  patients and dysphagia after  stroke  may also delay initiation of SSRI treatment in acute  stroke    As potential neuroprotective effects of SSRI appear to be frontloaded in ischemic  stroke , future trials need to ensure its early initiation in the hyperacute phase of  stroke  when      Thus, there were 52 trials randomizing 4059 patients to SSRI or control; 28 used fluoxetine, 2,7 – 32 7 used sertraline, 33 – 39 10 used paroxetine, 40 – 49 5 used citalopram, 50 – 54 1 used escitalopram, 55 and 1 used either sertraline or fluoxetine  56 The usual care arm was not the same in all the trials because of geographical variation in the management of stroke --- ncbi nlm nih gov pmc articles PMC8523983Search methods  For this update, we searched the Cochrane Stroke Group Trials Register (last searched 16 July 2018), the Cochrane Controlled Trials Register (CENTRAL, Issue 7 of 12, July 2018), MEDLINE (1946 to July 2018), Embase (1974 to July 2018), CINAHL (1982 July 2018), PsycINFO (1985 to July 2018), AMED (1985 to July 2018), and PsycBITE March 2012 to July 2018) 
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